Fructose metabolic process

Across TCGA cell cohorts, RNA activity of the Fructose metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1B1, TUFT1, and MCOLN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fructose metabolic process activity versus AKR1B1 in LUNG_NSCLC_LUAD (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKR1B1 →	+2.758	+0.384	<.001	<.001	3	7
STOMACH	TUFT1 →	-1.699	-0.309	<.001	<.001	3	6
SKIN	MCOLN3 →	+1.765	+0.141	.001	.008	3	6
BLOOD_Leukemia	CORT →	+0.317	+0.155	.002	<.001	3	6
LUNG_SCLC	OPTN →	-1.184	-0.261	<.001	<.001	3	6
KIDNEY	METTL27 →	+2.077	+0.205	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006000 vs AKR1B1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →