Monosaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Monosaccharide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAA50, EFEMP2, and CES1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide metabolic process activity versus NAA50 in LUAD (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NAA50 →	-0.191	-0.017	.004	.003	3	6
BRCA	EFEMP2 →	+0.570	+0.018	<.001	<.001	3	6
BRCA	CES1 →	+0.834	+0.026	<.001	<.001	3	5
OV	LENG8_S351 →	-0.783	-0.029	.001	<.001	3	5
CCRCC	SNX7 →	+0.266	+0.023	<.001	.002	3	5
BRCA	GPD1 →	+1.043	+0.018	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005996 vs NAA50 — LUAD

Explore this scatter interactively →