Monosaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Monosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN15, SMPD2, and TACO1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide metabolic process activity versus CLDN15 in COAD (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CLDN15 →	+2.522	+0.277	.002	.005	3	1
COAD	SMPD2 →	-0.583	-0.213	.003	.001	3	1
COAD	TACO1 →	-0.324	-0.272	.003	.006	3	1
COAD	RPS6 →	-0.436	-0.213	<.001	.001	3	1
COAD	TM7SF2 →	+1.162	+0.275	.002	.007	3	1
COAD	CACUL1 →	-0.406	-0.213	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005996 vs CLDN15 — COAD

Explore this scatter interactively →