Monosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Monosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf35, ERP44, and IFT88, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C3orf35 grouped by Monosaccharide metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C3orf35 →	-0.345	-1.021	.001	.005	3	4
BLOOD_Lymphoma	ERP44 →	-1.193	-0.342	.005	.002	3	4
KIDNEY	IFT88 →	-0.758	-1.027	.006	.005	3	3
OVARY	LIN7C →	-0.660	-0.706	.004	.007	3	3
CNS	ATG5 →	-0.418	-0.689	.008	.002	3	3
SKIN	ETV4 →	-0.819	-0.758	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C3orf35 by Monosaccharide metabolic process activity — KIDNEY

Explore this box plot interactively →