Monosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Monosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMC2, TBC1D16, and MRPS16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide metabolic process activity versus LAMC2 in STOMACH (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LAMC2 →	-4.104	-0.246	.001	.001	3	6
SKIN	TBC1D16 →	+2.695	+0.252	.004	.003	3	5
BREAST	MRPS16 →	+0.948	+0.199	<.001	.004	3	4
URINARY_TRACT	ACBD5 →	+0.899	+0.326	.001	<.001	3	4
URINARY_TRACT	MDM1 →	+0.997	+0.338	<.001	<.001	3	4
URINARY_TRACT	MTDH →	+0.878	+0.387	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005996 vs LAMC2 — STOMACH

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