Disaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Disaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDUA, FBP1, and GSAP, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disaccharide metabolic process activity versus IDUA in SCLC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	IDUA →	+1.373	+0.339	<.001	.004	2	25
LAML	FBP1 →	+1.623	+0.104	<.001	<.001	3	23
DLBC	GSAP →	+1.199	+0.053	<.001	.002	2	21
TGCT	TNFRSF14 →	+0.840	+0.045	<.001	<.001	3	20
SCLC	UBA7 →	+1.028	+0.262	<.001	.001	2	20
UVM	TCIRG1 →	+0.913	+0.050	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005984 vs IDUA — SCLC

Explore this scatter interactively →