Disaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Disaccharide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OBI1_S210, DDX21_S89, and ESF1_S153, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disaccharide metabolic process activity versus OBI1_S210 in LUAD (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OBI1_S210 →	-0.880	-0.099	<.001	<.001	3	8
BRCA	DDX21_S89 →	-0.881	-0.041	<.001	.001	3	7
LSCC	ESF1_S153 →	-0.946	-0.080	<.001	<.001	3	7
UCEC	FBP1 →	+0.678	+0.084	.002	.009	3	7
LUAD	NCL_S67 →	-0.780	-0.083	<.001	<.001	3	7
LUAD	COIL_T303 →	-0.818	-0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005984 vs OBI1_S210 — LUAD

Explore this scatter interactively →