Disaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Disaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TES, GTF2IRD2B, and GRID2IP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disaccharide metabolic process activity versus TES in GBM (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TES →	+0.831	+0.156	<.001	<.001	3	4
CCRCC	GTF2IRD2B →	+0.484	+0.179	.001	.005	3	3
CCRCC	GRID2IP →	+0.396	+0.178	.003	.002	3	3
CCRCC	TCAF1P1 →	+0.376	+0.197	.005	.002	3	3
BRCA	H3P13 →	+0.396	+0.116	.008	.008	3	3
GBM	RILP →	+0.381	+0.167	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005984 vs TES — GBM

Explore this scatter interactively →