Disaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Disaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBF4, GAA, and BCL2L2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Disaccharide metabolic process activity versus EBF4 in SKIN (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EBF4 →	+1.716	+1.952	.004	<.001	3	3
BLOOD_Leukemia	GAA →	+3.123	+2.229	<.001	<.001	3	3
LUNG_NSCLC_LUAD	BCL2L2 →	+1.094	+0.390	.002	.002	3	2
LUNG_NSCLC_LUAD	TMEM165 →	+0.916	+0.412	.001	.006	2	3
LUNG_NSCLC_LUAD	RTF1 →	+0.576	+0.390	.001	.002	3	2
LUNG_NSCLC_LUAD	C17orf80 →	+0.756	+0.490	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005984 vs EBF4 — SKIN

Explore this scatter interactively →