Regulation of glycogen catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of glycogen catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHKG2, ACAD10, and PPP1R3D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen catabolic process activity versus PHKG2 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PHKG2 →	+0.260	+0.067	<.001	<.001	3	6
UCEC	ACAD10 →	+0.338	+0.049	.005	.008	3	5
LSCC	PPP1R3D →	+0.415	+0.065	<.001	<.001	3	5
GBM	MRTFA →	-0.400	-0.073	<.001	<.001	3	5
GBM	EIF4ENIF1 →	-0.312	-0.065	<.001	<.001	3	4
LUAD	BCKDK →	+0.338	+0.031	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005981 vs PHKG2 — LSCC

Explore this scatter interactively →