Regulation of glycogen catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of glycogen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP12, KLF12, and KPNA5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen catabolic process activity versus THAP12 in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THAP12 →	-0.566	-0.134	.002	.006	3	6
UCEC	KLF12 →	-0.888	-0.139	<.001	.007	3	5
PDAC	KPNA5 →	-0.340	-0.243	<.001	.001	2	6
PDAC	ATM →	-0.268	-0.258	.001	.002	3	5
GBM	LY6G5B →	-0.487	-0.247	<.001	.001	3	5
HNSC	WDR7 →	-0.504	-0.132	.005	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005981 vs THAP12 — BRCA

Explore this scatter interactively →