Regulation of glycogen catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGT1, ZNF516, and WFIKKN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGT1 grouped by Regulation of glycogen catabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GGT1 →	-2.213	-0.924	.008	.004	3	3
BREAST	ZNF516 →	+0.922	+0.574	.007	.008	3	3
BREAST	WFIKKN1 →	+0.417	+0.633	.003	.005	3	3
BREAST	DRC3 →	+0.809	+0.632	<.001	.003	3	3
LUNG_NSCLC_LUAD	RAPGEF5 →	-0.866	-0.288	.003	.009	3	3
SOFT_TISSUE	CCDC125 →	-1.344	-0.272	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGT1 by Regulation of glycogen catabolic process activity — PANCREAS

Explore this box plot interactively →