Regulation of glycogen biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of glycogen biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ENPP1, ITSN1, and VCAN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen biosynthetic process activity versus ENPP1 in LSCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ENPP1 →	+0.725	+0.057	.001	<.001	3	7
BRCA	ITSN1 →	+0.274	+0.038	<.001	.001	3	6
OV	VCAN →	+0.869	+0.035	<.001	<.001	3	6
COAD	JPT1 →	-0.460	-0.036	.001	.001	3	6
BRCA	LARP4_S583 →	-0.301	-0.037	<.001	<.001	3	6
LSCC	FERMT2 →	+0.527	+0.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005979 vs ENPP1 — LSCC

Explore this scatter interactively →