Regulation of glycogen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1CB, PPP1R3B, and IGF2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1CB grouped by Regulation of glycogen biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPP1CB →	-0.621	-1.128	<.001	.001	2	11
BREAST	PPP1R3B →	-0.135	-0.546	.006	.008	2	7
SOFT_TISSUE	IGF2 →	-0.383	-1.082	<.001	.005	3	6
SOFT_TISSUE	PPP1R12A →	-0.339	-1.087	.005	<.001	3	5
SOFT_TISSUE	COL16A1 →	+0.184	+1.050	.004	.001	3	4
CNS	GNAL →	+0.239	+1.033	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1CB by Regulation of glycogen biosynthetic process activity — OVARY

Explore this box plot interactively →