Regulation of glycogen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBX, SARS1, and MED27, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBX grouped by Regulation of glycogen biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBX →	-1.389	-1.283	.001	<.001	3	5
BREAST	SARS1 →	-0.770	-0.974	.003	.001	3	5
OESOPHAGUS	MED27 →	-0.637	-0.880	.005	.008	3	5
OVARY	TTC26 →	-0.508	-1.203	.003	<.001	3	4
SOFT_TISSUE	HABP4 →	-1.140	-1.076	.002	.002	3	4
BREAST	OSMR →	-2.631	-0.991	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBX by Regulation of glycogen biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →