Regulation of glycogen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycogen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM36, GMIP, and AIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycogen biosynthetic process activity versus TRIM36 in BREAST (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TRIM36 →	-1.152	-0.709	.003	<.001	3	5
BREAST	GMIP →	+0.649	+0.824	.005	<.001	3	4
BONE	AIP →	+1.458	+1.194	<.001	<.001	3	4
BONE	PACS1 →	+1.399	+1.479	.004	<.001	3	4
BLOOD_Leukemia	PMP22 →	-1.576	-0.859	.002	<.001	3	4
BLOOD_Leukemia	HES6 →	-1.682	-0.650	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005979 vs TRIM36 — BREAST

Explore this scatter interactively →