Polysaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Polysaccharide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, DDX50_S82, and MKI67, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polysaccharide metabolic process activity versus DDX21_S89 in BRCA (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX21_S89 →	-1.347	-0.031	<.001	<.001	3	6
BRCA	DDX50_S82 →	-1.055	-0.039	<.001	<.001	3	6
LSCC	MKI67 →	-0.486	-0.028	.002	.004	3	6
BRCA	MPRIP →	+0.324	+0.031	.001	<.001	3	6
GBM	MKI67_S2528 →	-0.723	-0.037	<.001	<.001	3	6
BRCA	SMOC2 →	+1.005	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0005976 vs DDX21_S89 — BRCA

Explore this scatter interactively →