Chondrocyte development involved in endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Chondrocyte development involved in endochondral bone morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, ACTN4, and DNAJC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte development involved in endochondral bone morphogenesis activity versus SOX9 in LSCC (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOX9 →	+0.625	+0.118	<.001	<.001	3	6
LUAD	ACTN4 →	+0.224	+0.073	.001	<.001	3	5
BRCA	DNAJC1 →	-0.516	-0.047	.002	.005	3	5
OV	S100A10 →	+0.626	+0.080	.002	.001	3	5
HNSC	IGFBP3_S201 →	+0.905	+0.132	<.001	<.001	3	5
GBM	IGFBP7 →	+0.684	+0.055	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003433 vs SOX9 — LSCC

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