Chondrocyte development involved in endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Chondrocyte development involved in endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, KDELC1P1, and SNRPD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte development involved in endochondral bone morphogenesis activity versus SOX9 in HNSC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SOX9 →	+0.962	+0.231	.001	.005	3	4
HNSC	KDELC1P1 →	+0.665	+0.223	.002	<.001	3	4
LUAD	SNRPD3 →	+0.327	+0.411	.003	.001	3	3
LUAD	SLC1A2 →	+0.383	+0.351	<.001	.008	3	3
UCEC	AK9 →	+0.376	+0.460	.008	.009	3	3
LSCC	PDXDC1 →	+0.271	+0.355	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003433 vs SOX9 — HNSC

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