Chondrocyte development involved in endochondral bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Chondrocyte development involved in endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC120, RTKN, and TMC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC120 grouped by Chondrocyte development involved in endochondral bone morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC120 →	+1.261	+1.265	<.001	<.001	3	4
LUNG_NSCLC_LUAD	RTKN →	+1.409	+1.094	.002	.004	3	4
LARGE_INTESTINE	TMC4 →	+1.584	+0.794	.006	.009	3	4
BLOOD_Leukemia	VPS26C →	+0.914	+1.171	<.001	.002	3	3
BLOOD_Leukemia	GET1 →	+0.829	+1.192	<.001	.001	3	3
BLOOD_Leukemia	DCLRE1A →	+0.989	+1.146	.007	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC120 by Chondrocyte development involved in endochondral bone morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →