Growth plate cartilage chondrocyte development

Across TCGA patient cohorts, RNA activity of the Growth plate cartilage chondrocyte development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASAP2_S822, BRD3, and SOX9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth plate cartilage chondrocyte development activity versus ASAP2_S822 in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASAP2_S822 →	+0.232	+0.053	<.001	.002	3	5
COAD	BRD3 →	+0.255	+0.056	.001	.001	3	5
BRCA	SOX9 →	+0.760	+0.089	<.001	<.001	3	5
LSCC	DNAJC1 →	-0.357	-0.078	.004	.007	3	5
LUAD	PLEC_T3879 →	+0.722	+0.081	.001	.002	3	5
LUAD	PLEC_T4030 →	+0.722	+0.081	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003431 vs ASAP2_S822 — COAD

Explore this scatter interactively →