Growth plate cartilage chondrocyte development

Across TCGA patient cohorts, RNA activity of the Growth plate cartilage chondrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP31-AS1, GALNT11, and SLC39A10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth plate cartilage chondrocyte development activity versus ARHGAP31-AS1 in LSCC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP31-AS1 →	+0.526	+0.176	.001	<.001	3	5
HNSC	GALNT11 →	+0.669	+0.247	.001	<.001	3	4
HNSC	SLC39A10 →	+0.648	+0.263	<.001	.003	3	4
HNSC	TCAF1 →	+0.400	+0.231	.005	.007	3	4
UCEC	RASAL2 →	+0.424	+0.416	<.001	.001	3	4
CCRCC	TANC1 →	+0.392	+0.135	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003431 vs ARHGAP31-AS1 — LSCC

Explore this scatter interactively →