Growth plate cartilage chondrocyte development

Across TCGA cell cohorts, RNA activity of the Growth plate cartilage chondrocyte development pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARG, SOX9, and TSKU, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RARG grouped by Growth plate cartilage chondrocyte development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RARG →	-0.230	-1.007	<.001	<.001	3	13
STOMACH	SOX9 →	-0.326	-0.906	.001	.001	3	10
LUNG_SCLC	TSKU →	-0.309	-1.400	.001	.002	3	7
CNS	TGFBR2 →	-0.276	-1.226	<.001	<.001	3	7
CNS	POU2F1 →	-0.176	-0.853	.001	.008	3	5
LUNG_NSCLC_LUSC	NRG2 →	-0.356	-1.161	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RARG by Growth plate cartilage chondrocyte development activity — SKIN

Explore this box plot interactively →