Growth plate cartilage chondrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Growth plate cartilage chondrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM47, MFAP4, and LMNA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth plate cartilage chondrocyte differentiation activity versus TRIM47 in GBM (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM47 →	+0.215	+0.050	<.001	<.001	3	5
BRCA	MFAP4 →	+0.815	+0.038	<.001	<.001	3	5
GBM	LMNA →	+0.337	+0.069	<.001	<.001	3	5
LUAD	PLEC_T3879 →	+0.455	+0.044	.005	.002	3	5
LUAD	PLEC_T4030 →	+0.455	+0.044	.005	.002	3	5
COAD	CLPTM1L →	-0.257	-0.035	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003418 vs TRIM47 — GBM

Explore this scatter interactively →