Growth plate cartilage chondrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Growth plate cartilage chondrocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, TSKU, and RARG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX9 grouped by Growth plate cartilage chondrocyte differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SOX9 →	-0.373	-1.249	<.001	<.001	3	8
LUNG_SCLC	TSKU →	-0.213	-0.891	<.001	.001	3	7
BLOOD_Myeloma	RARG →	-0.246	-0.772	<.001	.006	3	6
STOMACH	IFT80 →	-0.338	-1.986	.001	<.001	3	5
LUNG_NSCLC_LUAD	STK16 →	-0.133	-0.609	.001	.004	3	5
LUNG_NSCLC_LUAD	HTR6 →	-0.155	-0.851	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX9 by Growth plate cartilage chondrocyte differentiation activity — STOMACH

Explore this box plot interactively →