Growth plate cartilage chondrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Growth plate cartilage chondrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGME1, XYLT1, and OXCT2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MGME1 grouped by Growth plate cartilage chondrocyte differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MGME1 →	-0.721	-1.628	<.001	<.001	3	3
BONE	XYLT1 →	-2.722	-1.510	.002	<.001	3	3
BONE	OXCT2 →	+0.332	+1.420	.002	.007	3	3
BLOOD_Leukemia	FAM149B1 →	+0.561	+1.390	<.001	<.001	3	3
BLOOD_Leukemia	SLC35G2 →	+1.264	+1.301	.002	.001	3	3
BLOOD_Leukemia	LLGL2 →	-1.400	-1.316	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MGME1 by Growth plate cartilage chondrocyte differentiation activity — LIVER

Explore this box plot interactively →