Chondrocyte hypertrophy

Across TCGA patient cohorts, RNA activity of the Chondrocyte hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP42, VGLL4, and PTPRG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte hypertrophy activity versus ARHGAP42 in HNSC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP42 →	+0.675	+0.200	<.001	<.001	3	5
BRCA	VGLL4 →	+0.516	+0.297	.002	.001	3	4
CCRCC	PTPRG →	+0.733	+0.276	<.001	<.001	3	4
HNSC	PRDX2P1 →	+0.773	+0.194	.002	.004	3	4
LSCC	TNFRSF10B →	+0.513	+0.186	.005	.003	3	4
CCRCC	DUSP6 →	+0.887	+0.248	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003415 vs ARHGAP42 — HNSC

Explore this scatter interactively →