Chondrocyte hypertrophy

Across TCGA patient cohorts, RNA activity of the Chondrocyte hypertrophy pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, TGFBR2, and TGFBR2_S548, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte hypertrophy activity versus SOX9 in HNSC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SOX9 →	+0.852	+0.279	<.001	<.001	2	6
CCRCC	TGFBR2 →	+0.491	+0.253	<.001	<.001	3	3
LUAD	TGFBR2_S548 →	+0.561	+0.212	<.001	<.001	3	3
GBM	MLXIP_S27 →	-0.820	-0.363	<.001	<.001	3	3
BRCA	NKAPD1_S285 →	+1.703	+0.295	<.001	<.001	3	3
UCEC	EPB41L3_S962 →	-0.701	-0.254	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003415 vs SOX9 — HNSC

Explore this scatter interactively →