Chondrocyte hypertrophy

Across TCGA cell cohorts, RNA activity of the Chondrocyte hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NICN1, KLHL25, and CAPN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NICN1 grouped by Chondrocyte hypertrophy-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NICN1 →	-1.027	-1.656	.002	.007	3	3
STOMACH	KLHL25 →	+0.914	+1.390	<.001	.009	3	3
SKIN	CAPN5 →	-1.602	-0.993	.007	.006	3	3
KIDNEY	DEPP1 →	+4.527	+2.240	.001	<.001	3	3
KIDNEY	P4HB →	+1.827	+1.853	.008	.007	3	3
LUNG_NSCLC_LUSC	GALK1 →	-1.060	-1.402	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NICN1 by Chondrocyte hypertrophy activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →