Chondrocyte differentiation involved in endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Chondrocyte differentiation involved in endochondral bone morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LARP4, USP15_S229, and CDK18_S89, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte differentiation involved in endochondral bone morphogenesis activity versus LARP4 in COAD (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LARP4 →	-0.264	-0.038	<.001	<.001	3	6
UCEC	USP15_S229 →	-0.414	-0.073	<.001	.001	3	5
COAD	CDK18_S89 →	+0.263	+0.026	.008	.005	3	5
COAD	KLC4 →	+0.397	+0.043	<.001	<.001	2	6
UCEC	MACROH2A2 →	+0.652	+0.088	<.001	<.001	3	5
BRCA	WDR19 →	+0.257	+0.031	.004	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003413 vs LARP4 — COAD

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