Chondrocyte differentiation involved in endochondral bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Chondrocyte differentiation involved in endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM210B, ZNF843, and C16orf72, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte differentiation involved in endochondral bone morphogenesis activity versus FAM210B in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM210B →	+0.630	+0.770	<.001	<.001	3	4
LUAD	ZNF843 →	+0.212	+0.406	.003	.001	3	4
UCEC	C16orf72 →	+0.283	+0.613	<.001	<.001	3	4
BRCA	CNIH3 →	+0.262	+0.452	.009	.003	3	4
BRCA	NPAP1P4 →	-0.013	-0.778	.001	.001	3	4
UCEC	ZNF720 →	+0.351	+0.609	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003413 vs FAM210B — UCEC

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