Chondrocyte differentiation involved in endochondral bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Chondrocyte differentiation involved in endochondral bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORC, CMC1, and ZDHHC6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNORC grouped by Chondrocyte differentiation involved in endochondral bone morphogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SNORC →	-0.923	-1.164	.009	.005	3	3
LUNG_NSCLC_LUSC	CMC1 →	-0.731	-1.301	.006	.002	3	3
OESOPHAGUS	ZDHHC6 →	+0.668	+0.748	<.001	.006	3	3
STOMACH	NDUFA4 →	+0.599	+1.069	.005	<.001	3	3
BLOOD_Leukemia	FAM149B1 →	+0.561	+1.390	<.001	<.001	3	3
BLOOD_Leukemia	SLC35G2 →	+1.264	+1.301	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNORC by Chondrocyte differentiation involved in endochondral bone morphogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →