Neural retina development

Across TCGA patient cohorts, RNA activity of the Neural retina development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMC8, TRAJ5, and STAB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural retina development activity versus TMC8 in UCEC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMC8 →	-0.549	-0.755	<.001	.003	3	4
OV	TRAJ5 →	-0.635	-0.460	.006	.006	3	4
GBM	STAB1 →	-0.642	-0.271	.002	<.001	3	4
OV	ANTXRLP1 →	-0.177	-0.629	.003	.006	3	4
GBM	ALDOB →	+0.627	+0.298	<.001	.005	3	3
UCEC	SIRPG →	-0.620	-0.716	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003407 vs TMC8 — UCEC

Explore this scatter interactively →