Neural retina development

Across TCGA cell cohorts, RNA activity of the Neural retina development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA1L, SLU7, and DNASE1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSPA1L grouped by Neural retina development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HSPA1L →	-0.458	-0.521	.002	.002	3	5
SKIN	SLU7 →	-0.580	-0.684	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	DNASE1L1 →	-0.984	-1.006	.006	.003	3	4
BLOOD_Myeloma	SDCBP →	+1.480	+1.863	.008	<.001	3	4
BLOOD_Myeloma	DUSP16 →	+1.467	+1.547	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CELF5 →	-0.092	-1.018	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSPA1L by Neural retina development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →