Retinal pigment epithelium development

Across TCGA patient cohorts, RNA activity of the Retinal pigment epithelium development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE4A, SRCIN1_S165, and MYO1C_S408, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal pigment epithelium development activity versus UBE4A in HNSC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBE4A →	+0.199	+0.060	.001	.002	3	4
CCRCC	SRCIN1_S165 →	+0.925	+0.130	<.001	<.001	3	4
CCRCC	MYO1C_S408 →	-0.313	-0.065	.003	.006	3	4
OV	KMT2D_S4738 →	-0.518	-0.055	<.001	<.001	3	4
GBM	ANK3_S1459 →	+0.648	+0.084	<.001	<.001	3	4
UCEC	PPM1H →	+0.546	+0.095	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003406 vs UBE4A — HNSC

Explore this scatter interactively →