Axis elongation

Across TCGA patient cohorts, RNA activity of the Axis elongation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTK7, SEC24A, and PSMB10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axis elongation activity versus PTK7 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PTK7 →	+0.448	+0.072	<.001	<.001	3	8
LSCC	SEC24A →	-0.358	-0.069	<.001	<.001	3	7
LSCC	PSMB10 →	-0.353	-0.047	<.001	<.001	3	7
LSCC	ITGAL →	-0.536	-0.061	<.001	<.001	3	6
OV	RAI14 →	+0.448	+0.070	<.001	.001	3	6
BRCA	FKBP7 →	+0.450	+0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003401 vs PTK7 — OV

Explore this scatter interactively →