Axis elongation

Across TCGA patient cohorts, RNA activity of the Axis elongation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENG1, GIT1, and MSI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axis elongation activity versus LENG1 in CCRCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LENG1 →	+0.341	+0.572	<.001	<.001	3	4
CCRCC	GIT1 →	+0.274	+0.499	<.001	<.001	3	4
CCRCC	MSI1 →	+0.180	+0.470	.001	.001	3	4
CCRCC	TTC7B →	+0.250	+0.443	.002	.002	3	4
LSCC	HNRNPM →	+0.349	+0.307	.001	.006	3	4
LSCC	CERS5 →	+0.344	+0.409	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003401 vs LENG1 — CCRCC

Explore this scatter interactively →