Sphingosine-1-phosphate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Sphingosine-1-phosphate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K8, DSCC1, and PTP4A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingosine-1-phosphate receptor signaling pathway activity versus MAP3K8 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP3K8 →	+0.277	+0.374	.007	.003	3	4
BRCA	DSCC1 →	-0.651	-0.125	.002	<.001	3	4
HNSC	PTP4A3 →	-0.683	-0.529	.009	.006	3	3
HNSC	IMPDH1P8 →	-0.369	-0.609	.009	<.001	2	4
LSCC	CENPI →	-0.469	-0.653	.004	<.001	3	3
LSCC	FBL →	-0.540	-0.453	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003376 vs MAP3K8 — LSCC

Explore this scatter interactively →