Sphingosine-1-phosphate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Sphingosine-1-phosphate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRAG1, MACROD1, and IFT46, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRAG1 grouped by Sphingosine-1-phosphate receptor signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRAG1 →	+2.571	+1.805	<.001	<.001	3	4
STOMACH	MACROD1 →	-1.451	-1.248	.008	.005	3	4
LUNG_NSCLC_LUSC	IFT46 →	+1.529	+1.321	.005	.005	3	4
SOFT_TISSUE	RNF207 →	-2.580	-1.377	.003	.008	3	3
SOFT_TISSUE	CSDC2 →	+1.300	+1.152	.004	.003	3	3
SOFT_TISSUE	MLLT10 →	-0.608	-1.454	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRAG1 by Sphingosine-1-phosphate receptor signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →