Brainstem development

Across TCGA cell cohorts, RNA activity of the Brainstem development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRR, RABGEF1, and NFU1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRR grouped by Brainstem development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SRR →	+1.315	+1.527	.008	.007	3	4
LUNG_SCLC	RABGEF1 →	+0.527	+0.362	.004	.007	3	4
LUNG_NSCLC_LUSC	NFU1 →	+0.716	+0.315	.009	.003	3	4
LUNG_NSCLC_LUSC	ZBTB38 →	+1.523	+0.306	.004	.006	3	4
UPPER_AERODIGESTIVE_TRACT	RAB40A →	+0.743	+0.332	.009	.001	3	4
BLOOD_Leukemia	CWC15 →	+0.385	+0.324	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRR by Brainstem development activity — BLOOD_Myeloma

Explore this box plot interactively →