Brainstem development

Across TCGA cell cohorts, RNA activity of the Brainstem development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM59, RRP1B, and TEP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Brainstem development activity versus TMEM59 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM59 →	-1.021	-0.177	.003	.007	3	5
LUNG_SCLC	RRP1B →	+0.528	+0.160	.009	.008	3	5
CNS	TEP1 →	-1.889	-0.483	<.001	.004	3	4
BLOOD_Leukemia	MTRNR2L8 →	-0.625	-0.067	.004	.009	2	5
LUNG_SCLC	PLSCR4 →	-1.197	-0.195	.004	.006	3	4
LUNG_SCLC	PPL →	-1.429	-0.255	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003360 vs TMEM59 — LUNG_SCLC

Explore this scatter interactively →