Noradrenergic neuron development

Across TCGA patient cohorts, RNA activity of the Noradrenergic neuron development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ORC4, LSM14B, and SKAP2_S283, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Noradrenergic neuron development activity versus ORC4 in BRCA (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ORC4 →	+0.142	+0.083	.006	<.001	3	5
COAD	LSM14B →	+0.259	+0.070	.002	.001	3	5
LUAD	SKAP2_S283 →	-0.623	-0.147	.005	.002	2	6
OV	CBX2 →	+1.110	+0.108	<.001	<.001	3	4
OV	PRTFDC1 →	+0.420	+0.070	.001	<.001	3	4
BRCA	SF3B3 →	+0.138	+0.093	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003358 vs ORC4 — BRCA

Explore this scatter interactively →