Noradrenergic neuron development

pathway activity — cross-omics
GO:0003358Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Noradrenergic neuron development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS7P3, RPL13AP7, and RPL26P6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCARPS7P3 →+1.504+0.811<.001<.00135
BRCARPL13AP7 →+1.237+0.597.001<.00134
BRCARPL26P6 →+0.738+0.550.004.00234
HNSCMORF4L1P3 →+0.979+0.708<.001.00134
PDACNUDT13 →+0.392+0.098.001.00234
PDACSRP9P1 →+0.532+0.104.001.00234
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration