Noradrenergic neuron development

Across TCGA cell cohorts, RNA activity of the Noradrenergic neuron development pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK10, AUTS2, and ZBTB34, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DOCK10 grouped by Noradrenergic neuron development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DOCK10 →	+0.151	+0.188	.001	<.001	3	4
LUNG_SCLC	AUTS2 →	-0.188	-1.891	.001	<.001	3	4
URINARY_TRACT	ZBTB34 →	-0.310	-0.216	.009	.004	3	3
LUNG_NSCLC_LUAD	ZNF655 →	+0.112	+0.171	<.001	<.001	3	3
OESOPHAGUS	ST13 →	+0.158	+0.173	<.001	.003	3	3
OESOPHAGUS	ATP5PD →	+0.188	+0.137	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DOCK10 by Noradrenergic neuron development activity — URINARY_TRACT

Explore this box plot interactively →