Noradrenergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Noradrenergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX4, RNU7-20P, and ZSCAN16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Noradrenergic neuron differentiation activity versus SOX4 in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX4 →	+1.427	+0.424	<.001	<.001	3	6
CCRCC	RNU7-20P →	+0.803	+0.142	.007	.003	2	6
HNSC	ZSCAN16 →	+0.682	+0.239	.004	.007	2	6
COAD	FNBP1L →	+0.373	+0.179	.001	.004	3	5
COAD	C2orf15 →	+0.586	+0.204	<.001	<.001	3	5
UCEC	CBX2 →	+1.139	+0.262	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003357 vs SOX4 — GBM

Explore this scatter interactively →