Noradrenergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Noradrenergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, PUM2, and MAP3K20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AOC3 grouped by Noradrenergic neuron differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AOC3 →	+0.637	+0.756	.008	.005	3	4
LARGE_INTESTINE	PUM2 →	+0.309	+0.705	.009	.002	3	4
SKIN	MAP3K20 →	+0.659	+0.592	.005	.007	3	4
LARGE_INTESTINE	METAP1 →	+0.657	+0.800	.001	.005	3	3
STOMACH	PODXL →	-3.218	-0.286	<.001	.003	3	3
STOMACH	ZNF92 →	+1.026	+0.327	.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AOC3 by Noradrenergic neuron differentiation activity — LARGE_INTESTINE

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