Regulation of cilium beat frequency

Across TCGA patient cohorts, RNA activity of the Regulation of cilium beat frequency pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNALI1, IFT46, and TRAF3IP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium beat frequency activity versus DNALI1 in CCRCC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DNALI1 →	+0.905	+0.085	.002	.003	3	7
BRCA	IFT46 →	+0.375	+0.054	<.001	<.001	3	6
UCEC	TRAF3IP1 →	+0.388	+0.153	<.001	<.001	3	6
UCEC	IFT88 →	+0.394	+0.143	<.001	<.001	3	6
UCEC	OSCP1 →	+0.595	+0.154	<.001	<.001	3	6
BRCA	LZTFL1 →	+0.579	+0.086	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003356 vs DNALI1 — CCRCC

Explore this scatter interactively →