Regulation of cilium beat frequency

Across TCGA patient cohorts, RNA activity of the Regulation of cilium beat frequency pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC39A, RNU6-833P, and COLEC11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium beat frequency activity versus TTC39A in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTC39A →	+0.700	+0.412	.002	<.001	3	4
HNSC	RNU6-833P →	+0.969	+0.493	.001	.006	3	3
LUAD	COLEC11 →	+0.551	+0.453	.002	.001	3	3
PDAC	ID3 →	+0.860	+0.116	<.001	<.001	3	2
PDAC	RHOB →	+0.574	+0.080	.004	.007	3	2
PDAC	C1QTNF7 →	+0.728	+0.073	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003356 vs TTC39A — BRCA

Explore this scatter interactively →