Regulation of cilium beat frequency

Across TCGA cell cohorts, RNA activity of the Regulation of cilium beat frequency pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL6, CPAMD8, and SMARCD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL6 grouped by Regulation of cilium beat frequency-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPL6 →	-0.575	-1.096	.001	.008	3	5
BREAST	CPAMD8 →	+1.349	+0.732	.004	.009	3	5
OESOPHAGUS	SMARCD3 →	+1.857	+1.256	.001	.005	3	4
BLOOD_Lymphoma	THRA →	+2.341	+1.840	.006	<.001	3	4
CNS	AGFG2 →	+0.883	+0.690	.002	.007	3	4
UPPER_AERODIGESTIVE_TRACT	SMS →	-1.565	-1.882	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL6 by Regulation of cilium beat frequency activity — SKIN

Explore this box plot interactively →