Regulation of cilium beat frequency

Across TCGA cell cohorts, RNA activity of the Regulation of cilium beat frequency pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3A, BRD8, and PFDN1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium beat frequency activity versus FNDC3A in PANCREAS (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FNDC3A →	-0.766	-1.838	.005	<.001	3	2
PANCREAS	BRD8 →	+1.173	+1.838	.005	<.001	3	2
PANCREAS	PFDN1 →	+1.356	+1.838	<.001	<.001	3	2
PANCREAS	ACADS →	-1.719	-1.838	.008	<.001	3	2
PANCREAS	VSTM2L →	-3.343	-1.838	<.001	<.001	3	2
PANCREAS	PTGFRN →	-2.666	-1.838	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003356 vs FNDC3A — PANCREAS

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